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COVID-19 Human IgM IgG ELISA kit(Nucleocapsid Protein)

96T ¥150,000

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Manual

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Specification

Measurement method:   Indirect ELISA

Measurement wavelength:   450 nm

Measurement sample:   Serum

Species reactivity:    Human

Storage temperature:   Store at 2-8 ° C

Expiration date:   This product is valid for 12 months after production.

Immobilized antigen: SARS-CoV-2 nucleocapsid protein (Full length, E. coli expression system)

Kit contents

1. SARS-CoV-2 nucleocapsid protein-immobilized plate

2. HRP-conjugated anti-human IgM antibody

3. HRP-conjugated anti-human IgG antibody

4. Wash buffer(10× PBST)

5. Bovine serum albumin (for diluent)

6. Diluent buffer (10× )

7. R-1: Chromogenic substrate (TMB)

8. R-2: Stop reagent (1 mol/L hydrochloric acid)

9. Microplate seal

×2

20 μL×1

20 μL×1

100 mL×1

×1

50 mL×1

22 mL×1

22 mL×1

×2

Measurement principle

  1. The SARS-CoV-2 recombinant nucleocapsid protein on an immobilized plate is reacted with an antibody (hereinafter referred to as human IgM/IgG) in a sample that recognizes it.

  2. After the reaction, the sample is removed by washing.

  3. React with human IgM/IgG on immobilized plates with HRP (horseradish peroxidase)- conjugated anti-human IgM/IgG antibodies.

  4. Remove excess HRP-conjugated anti-human IgM/IgG antibodies by washing. Add a chromogenic substrate and measure the absorbance.

Significance of measurement

This kit is a research ELISA kit to detect human IgM and IgG antibodies that recognize the

nucleocapsid protein of SARS-CoV-2, the causative virus of Covid-19.
Virus detection can be broadly divided into two approaches: one is to detect the virus itself,

such as PCR method, and the other is to detect the immune response that develops during infection (IgG, IgM, IgA). In common infections, IgM is an antibody produced early in the infection and disappears with relief of symptoms. IgG begins to be produced later than IgM and continues to be produced for months after healing. This is known to reduce the symptoms of the next infection or to prevent the onset of the next infection.

Publications using this product

      J Med Virol. 2021 Feb 23. PubMed PMID: 33620098.

Related literature

      Epidemiol Infect. 2021 Jun. PubMed PMID: 34099081

      BMC Infect Dis. 2021 May. PubMed PMID: 34039287

      Int J Infect Dis. 2021 Mar. PubMed PMID: 33383223

      Front Immunol. 2021 May. PubMed PMID: 34012450

  • Marie-Luise Buchholtz et al.
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  • Kissy Guevara-Hoyer et al.
    Serological Tests in the Detection of SARS-CoV-2 Antibodies​​

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  • Daniel K. Jin et al.
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  • Robert M Humble et al.
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      Trop Med Int Health. 2021 Mar. PubMed PMID: 33666297

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      Nat Commun. 2021 Feb. PubMed PMID: 33563974

  • Andrea Tešija Kuna et al.
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      Biochem Med (Zagreb). 2021 Feb. PubMed PMID: 33594297

  • Hadeel T Al-Jighefee et al.
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  • Hadi M. Yassine et al.
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      PLoS One. 2021 Feb. PubMed PMID: 33529223

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      Diagnostics (Basel). 2021 Jan 6. PubMed PMID: 33418886

  • Ling L et al.
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      J Transl Med. 2021 Jan 7. PubMed PMID: 33413461

  • Sanne Jespersen et al.
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      Version 1. bioRxiv. 2020 Mar. PubMed PMID: 32511324

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      Lancet Infect Dis. 2020 Dec. PubMed PMID: 32758438

  • Christina A Rostad et al.
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      Pediatrics. 2020 Dec. PubMed PMID: 32879033

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      Nat Commun. 2020 Nov 27. PubMed PMID: 33247152

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      PLoS One. 2020 Nov 23. PubMed PMID: 33227020

  • Baweleta Isho et al.
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      Sci Immunol. 2020 Oct 8. PubMed PMID: 33033173

  • Anges Yadouleton et al.
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      Emerg Infect Dis. 2020 Dec 1. PubMed PMID: 33261717

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      Rev Esp Quimioter. 2020 Sep 18. PubMed PMID: 32945157

  • Martin Risch et al.
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      Biomed Res Int. 2020. PubMed PMID: 33224987

  • Ainhoa Gutiérrez-Cobos et al.
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      Eur J Clin Microbiol Infect Dis. 2020 Nov 24. PubMed PMID: 33236268

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      medRxiv. Preprint. 2020 Nov 16. PubMed PMID: 33236029

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      J Clin Med. 2020 Nov 21. PubMed PMID: 33233405

  • Shamez N Ladhani et al.
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      EClinicalMedicine. 2020 Nov 6. PubMed PMID: 33173854

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      Eur J Clin Microbiol Infect Dis. 2020 Nov 12. PubMed PMID: 33184753

  • Melkon G DomBourian et al.
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      J Immunol Methods. 2020 Nov. PubMed PMID: 32828791

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      Transfusion. 2020 Aug. PubMed PMID: 32627216

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  • Phuong Nguyen-Contant et al.
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       mBio. 2020 Sep 25. PubMed PMID: 32978311

  • James R. Byrnes et al.
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  • Tyler J Ripperger et al.
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  • Pedro Martínez-Fleta et al.
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       J Immunol. 2020 Nov 4. PubMed PMID: 33148714

  • Eshan U Patel et al.
    Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers

       J Clin Microbiol. 2020 Nov 2. PubMed PMID: 33139419

  • Zahra Rikhtegaran Tehrani et al.
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       PLoS One. 2020 Nov 2. PubMed PMID: 33137138

  • Bernd Jahrsdörfer et al.
    Independent side-by-side validation and comparison of four serological platforms for SARS-CoV-2 antibody testing

       J Infect Dis. 2020 Oct 16. PubMed PMID: 33064789

  • Xiaohui Wang et al.
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       mBio . 2020 Oct 20. PubMed PMID: 33082264

  • Zhaoqing Lyu et al.
    Serological Tests for SARS-CoV-2 Coronavirus by Commercially Available Point-of-Care and Laboratory Diagnostics in Pre-COVID-19 Samples in Japan

       Diseases. 2020 Sep 23. PubMed PMID: 32977485

  • Gláucia Cota et al.
    Diagnostic performance of commercially available COVID-19 serology tests in Brazil

       Int J Infect Dis. 2020 Oct 9. PubMed PMID: 33039612

  • Álvaro A Faccini-Martínez et al.
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       Int J Infect Dis. 2020 Sep 28. PubMed PMID: 33002616

  • Tao Li et al.
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       Front Cell Infect Microbiol. 2020 Sep 4. PubMed PMID: 33014893

  • Nguyen N Nguyen et al.
    Correlation of ELISA method with three other automated serological tests for the detection of anti-SARS-CoV-2 antibodies

       PLoS One. 2020 Oct 6. PubMed PMID: 33022019

  • Elitza S Theel et al.
    Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2

       J Clin Microbiol. 2020 Jul 23. PubMed PMID: 32513859

  • Pauline H Herroelen et al.
    Humoral Immune Response to SARS-CoV-2

       Am J Clin Pathol. 2020 Aug 18. PubMed PMID: 32808976

  • Anna E Merrill et al.
    Head-to-Head Comparison of Two SARS-CoV-2 Serology Assays

       J Appl Lab Med. 2020 Jul 27. PubMed PMID: 32717056

  • Marzia Nuccetelli et al.
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       Immunol Invest. 2020 Sep 18. PubMed PMID: 32945214

  • Suzanne Pickering et al.
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      PLoS Pathog . 2020 Sep 24. PubMed PMID: 32970782

  • Zeno Bisoffi et al.
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      Diagnostics (Basel). 2020 Sep 3. PubMed PMID: 32899333

  • Eshan Patel et al.
    Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers

      medRxiv . 2020 Sep 2. PubMed PMID: 32908987

  • Georg M. N. Behrens et al.
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      Infect Dis Ther. 2020 Sep 4. PubMed PMID: 32886335

  • Niko Kohmer et al.
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      J Clin Virol. 2020 Aug. PubMed PMID: 32505777

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      Chin Med J (Engl). 2020 Jun 20. PubMed PMID: 32221133

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      Res Sq. 2020 Aug 14. PubMed PMID: 32818217

  • Jeffrey D Whitman et al.
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  • Marie Tré‐Hardy et al.
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      EJ Med Virol. 2020 Jul 27. PubMed PMID: 32667733

  • Baoqing Sun et al.
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      Emerg Microbes Infect. 2020 Dec. PubMed PMID: 32357808

  • Kathleen M McAndrews et al.
    Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications on COVID-19 immunity

      JCI Insight. 2020 Aug 14. PubMed PMID: 32796155

  • Zahra Rikhtegaran Tehrani et al.
    Specificity and Performance of Nucleocapsid and Spike-based SARS-CoV-2 Serologic Assays

      medRxiv. 2020 Aug 7. PubMed PMID: 32793933

  • Jitendra Prasad Mathuria et al.
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      J Infect Public Health. 2020 Jul. PubMed PMID: 32534946

  • Alexander Krüttgen et al.
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      J Clin Virol. 2020 Jul. PubMed PMID: 32416599

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    Diagnostic Accuracy of Serological Tests for covid-19: Systematic Review and Meta-Analysis

      BMJ. 2020 Jul. PubMed PMID: 32611558

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    Laboratory Tests for COVID-19: A Review of Peer-Reviewed Publications and Implications for Clinical UIse

      Mo Med. 2020 May-Jun. PubMed PMID: 32636542

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       Antibody tests for identification of current and past infection with SARS-CoV-2

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       coronaviruses SARS-CoV and MERS-CoV

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    The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctor

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    Serological Differentiation Between COVID-19 and SARS Infections

      Emerg Microbes Infect. 2020 Jun 12. PubMed PMID: 32529906

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      Nat Med. 2020 Jun 5. PubMed PMID: 32504052​​​

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    Evaluation of Nucleocapsid and Spike Protein-Based Enzyme-Linked Immunosorbent Assays for Detecting Antibodies Against SARS-CoV-2

      J Clin Microbiol . 2020 May 26. PubMed PMID: 32229605​

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    Detection of serum IgM and IgG for COVID-19 diagnosis

      Sci China Life Sci. 2020 May. PubMed PMID: 32270436

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    A Serological Assay to Detect SARS-CoV-2 Seroconversion in Humans
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    Interpreting Diagnostic Tests for SARS-CoV-2
    JAMA. 2020;323(22):2249-2251. PubMed PMID: 32374370

  • Libo Zhang et al.
    Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19
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  • Hongzhou Lu et al.
    An Evolving Approach to the Laboratory Assessment of COVID-19
    J Med Virol . 2020 Apr 29. PubMed PMID: 32347966

  • Sarah Ee Fang Yong et al.
    Connecting clusters of COVID-19: an epidemiological and serological investigation
    Lancet Infect Dis. 2020 Apr 21. PubMed PMID: 32330439

  • Fei Xiang et al.
    Antibody Detection and Dynamic Characteristics in Patients With COVID-19
    Clin Infect Dis. 2020 Apr 19. PubMed PMID: 32306047

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    Antibody Responses to SARS-CoV-2 in Patients of Novel Coronavirus Disease 2019
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    2221519

  • Li Guo et al.
    Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
    Clin Infect Dis. 2020 Mar 21. PubMed PMID: 32198501

      PLoS One. 2021 May. PubMed PMID: 33984048

      Diagnostics (Basel). 2021 Apr. PubMed PMID: 33918840​​

      PLoS One. 2021 Apr. PubMed PMID: 33909646

      Front Immunol. 2021 Apr. PubMed PMID: 33897682

      Pract Lab Med. 2021 May. PubMed PMID: 33898689

      Acad Pathol. 2021 Apr. PubMed PMID: 33889715

      ACS Omega. 2021 Apr. PubMed PMID: 33869946

      mSphere. 2021 Apr. PubMed PMID: 33883259

      Gene Rep. 2021 Jun. PubMed PMID: 33869895

      J Infect Chemother. 2021 Feb. PubMed PMID: 33388232

      Virol J. 2020. PubMed PMID: 33187528

      Diagnostics (Basel). 2021 Mar. PubMed PMID: 33803299

      Euro Surveill. 2021 Apr. PubMed PMID: 33797390

      medRxiv. Preprint. 2021 Mar. PubMed PMID: 33791723

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