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COVID-19 Human IgM IgG ELISA kit(Nucleocapsid Protein)

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​96T　￥150,000

​（tax excluded）

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Manual

​SDS

Flyer

Specification

Measurement method:　　　Indirect ELISA

Measurement wavelength:　　　450 nm

Measurement sample:　　　Serum

Species reactivity:　　　　Human

Storage temperature:　　　Store at 2-8 ° C

Expiration date:   This product is valid for 12 months after production.

Immobilized antigen:　SARS-CoV-2 nucleocapsid protein (Full length, E. coli expression system)

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Kit contents

1. SARS-CoV-2 nucleocapsid protein-immobilized plate

2. HRP-conjugated anti-human IgM antibody

3. HRP-conjugated anti-human IgG antibody

4. Wash buffer(10× PBST)

5. Bovine serum albumin (for diluent)

6. Diluent buffer (10× )

7. R-1: Chromogenic substrate (TMB)

8. R-2: Stop reagent (1 mol/L hydrochloric acid)

9. Microplate seal

×2

20 μL×1

20 μL×1

100 mL×1

×1

50 mL×1

22 mL×1

22 mL×1

×2

Measurement principle

  1. The SARS-CoV-2 recombinant nucleocapsid protein on an immobilized plate is reacted with an antibody (hereinafter referred to as human IgM/IgG) in a sample that recognizes it.

  2. After the reaction, the sample is removed by washing.

  3. React with human IgM/IgG on immobilized plates with HRP (horseradish peroxidase)- conjugated anti-human IgM/IgG antibodies.

  4. Remove excess HRP-conjugated anti-human IgM/IgG antibodies by washing. Add a chromogenic substrate and measure the absorbance.

EN_測定図(Nucleocapsid Protein).png

Significance of measurement

This kit is a research ELISA kit to detect human IgM and IgG antibodies that recognize the

nucleocapsid protein of SARS-CoV-2, the causative virus of Covid-19.
Virus detection can be broadly divided into two approaches: one is to detect the virus itself,

such as PCR method, and the other is to detect the immune response that develops during infection (IgG, IgM, IgA). In common infections, IgM is an antibody produced early in the infection and disappears with relief of symptoms. IgG begins to be produced later than IgM and continues to be produced for months after healing. This is known to reduce the symptoms of the next infection or to prevent the onset of the next infection.

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Publications using this product

      J Med Virol. 2021 Feb 23. PubMed PMID: 33620098.

Related literature

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  • Eshan U Patel et al.
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       J Clin Microbiol. 2020 Nov 2. PubMed PMID: 33139419

  • Zahra Rikhtegaran Tehrani et al.
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  • Bernd Jahrsdörfer et al.
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       J Infect Dis. 2020 Oct 16. PubMed PMID: 33064789​

  • Xiaohui Wang et al.
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       Diseases. 2020 Sep 23. PubMed PMID: 32977485

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  • Álvaro A Faccini-Martínez et al.
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       Int J Infect Dis. 2020 Sep 28. PubMed PMID: 33002616

  • Tao Li et al.
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       Front Cell Infect Microbiol. 2020 Sep 4. PubMed PMID: 33014893

  • Nguyen N Nguyen et al.
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       PLoS One. 2020 Oct 6. PubMed PMID: 33022019

  • Elitza S Theel et al.
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       J Clin Microbiol. 2020 Jul 23. PubMed PMID: 32513859

  • Pauline H Herroelen et al.
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       Am J Clin Pathol. 2020 Aug 18. PubMed PMID: 32808976

  • Anna E Merrill et al.
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      PLoS Pathog . 2020 Sep 24. PubMed PMID: 32970782

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      Diagnostics (Basel). 2020 Sep 3. PubMed PMID: 32899333

  • Eshan Patel et al.
    Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers

      medRxiv . 2020 Sep 2. PubMed PMID: 32908987

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      Chin Med J (Engl). 2020 Jun 20. PubMed PMID: 32221133

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  • Jeffrey D Whitman et al.
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      EJ Med Virol. 2020 Jul 27. PubMed PMID: 32667733

  • Baoqing Sun et al.
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      Emerg Microbes Infect. 2020 Dec. PubMed PMID: 32357808

  • Kathleen M McAndrews et al.
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      JCI Insight. 2020 Aug 14. PubMed PMID: 32796155

  • Zahra Rikhtegaran Tehrani et al.
    Specificity and Performance of Nucleocapsid and Spike-based SARS-CoV-2 Serologic Assays

      medRxiv. 2020 Aug 7. PubMed PMID: 32793933

  • Jitendra Prasad Mathuria et al.
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      J Infect Public Health. 2020 Jul. PubMed PMID: 32534946

  • Alexander Krüttgen et al.
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      J Clin Virol. 2020 Jul. PubMed PMID: 32416599

  • Mayara Lisboa Bastos et al.
    Diagnostic Accuracy of Serological Tests for covid-19: Systematic Review and Meta-Analysis

      BMJ. 2020 Jul. PubMed PMID: 32611558

  • Lei Liu et al.
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      Microbes Infect. 2020 May-June. PubMed PMID: 32425648​

  • Patrick Sean Sullivan et al.
    Detection of SARS-CoV-2 RNA and Antibodies in Diverse Samples: Protocol to Validate the Sufficiency of Provider-Observed, Home-Collected Blood, Saliva, and Oropharyngeal Samples

      JMIR Public Health Surveill. 2020 Apr-Jun. PubMed PMID: 32310815

  • Daniel Shyu et al.
    Laboratory Tests for COVID-19: A Review of Peer-Reviewed Publications and Implications for Clinical UIse

      Mo Med. 2020 May-Jun. PubMed PMID: 32636542

  • Jonathan J Deeks et al.

       Antibody tests for identification of current and past infection with SARS-CoV-2

       Cochrane Database Syst Rev. 2020 Jun 25. PubMed PMID: 32584464

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       Review of Current Advances in Serologic Testing for COVID-19

       Am J Clin Pathol. 2020 Jun 25. PubMed PMID: 32583852

  •   Ahidjo Ayouba et al.

       Multiplex detection and dynamics of IgG antibodies to SARS-CoV2 and the highly pathogenic human

       coronaviruses SARS-CoV and MERS-CoV

　　J Clin Virol. 2020 Jun 22. PubMed PMID: 32623350

  • Antonio Vittorino Gaddi et al
    The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctor

      Int J Mol Sci. 2020 Jun. PubMed PMID: 32580529

  • Feng-Cai Zhu et al.
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      Lancet. 2020 13-19 June. PubMed PMID: 32450106

  • Wan Ni Chia et al.
    Serological Differentiation Between COVID-19 and SARS Infections

      Emerg Microbes Infect. 2020 Jun 12. PubMed PMID: 32529906

  • Christian Bundschuh et al.
    Evaluation of the EDI enzyme linked immunosorbent assays for the detection of SARS-CoV-2 IgM and IgG antibodies in human plasma

      Clin Chim Acta. 2020 Oct. PubMed PMID: 32526218

  • Xin Xu et al.
    Seroprevalence of Immunoglobulin M and G Antibodies Against SARS-CoV-2 in China

      Nat Med. 2020 Jun 5. PubMed PMID: 32504052​​​

  • Florian Krammer et al.
    Serology assays to manage COVID-19

      Science. 2020 Jun 5. PubMed PMID: 32414781​

  • Huan Ma et al.
    Serum IgA, IgM, and IgG responses in COVID-19

      Cell Mol Immunol. 2020 May 28. PubMed PMID: 32467617​

  • Nadin Younes et al.
    Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2

      Viruses. 2020 May 26. PubMed PMID: 32466458

  • Wanbing Liu et al.
    Evaluation of Nucleocapsid and Spike Protein-Based Enzyme-Linked Immunosorbent Assays for Detecting Antibodies Against SARS-CoV-2

      J Clin Microbiol . 2020 May 26. PubMed PMID: 32229605​

  • Ling Zhong et al.
    Detection of serum IgM and IgG for COVID-19 diagnosis

      Sci China Life Sci. 2020 May. PubMed PMID: 32270436

  • Fatima Amanat et al.
    A Serological Assay to Detect SARS-CoV-2 Seroconversion in Humans
    Nat Med. 2020 May 12. PubMed PMID: 32511441

  • Nandini Sethuraman et al.
    Interpreting Diagnostic Tests for SARS-CoV-2
    JAMA. 2020;323(22):2249-2251. PubMed PMID: 32374370

  • Libo Zhang et al.
    Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19
    Aging (Albany NY). 2020 Apr 30. PubMed PMID: 32320384

  • Hongzhou Lu et al.
    An Evolving Approach to the Laboratory Assessment of COVID-19
    J Med Virol . 2020 Apr 29. PubMed PMID: 32347966

  • Sarah Ee Fang Yong et al.
    Connecting clusters of COVID-19: an epidemiological and serological investigation
    Lancet Infect Dis. 2020 Apr 21. PubMed PMID: 32330439

  • Fei Xiang et al.
    Antibody Detection and Dynamic Characteristics in Patients With COVID-19
    Clin Infect Dis. 2020 Apr 19. PubMed PMID: 32306047

  • Juanjuan Zhao et al.
    Antibody Responses to SARS-CoV-2 in Patients of Novel Coronavirus Disease 2019
    Cin Infect Dis. 2020 Mar 28. PubMed PMID: 3    2221519

  • Li Guo et al.
    Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)
    Clin Infect Dis. 2020 Mar 21. PubMed PMID: 32198501

      PLoS One. 2021 May. PubMed PMID: 33984048

      Diagnostics (Basel). 2021 Apr. PubMed PMID: 33918840​​

      PLoS One. 2021 Apr. PubMed PMID: 33909646

      Front Immunol. 2021 Apr. PubMed PMID: 33897682

      Pract Lab Med. 2021 May. PubMed PMID: 33898689

      Acad Pathol. 2021 Apr. PubMed PMID: 33889715

      ACS Omega. 2021 Apr. PubMed PMID: 33869946

      mSphere. 2021 Apr. PubMed PMID: 33883259

      Gene Rep. 2021 Jun. PubMed PMID: 33869895

      J Infect Chemother. 2021 Feb. PubMed PMID: 33388232

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